Actively Recruiting
Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery
Led by Peking University First Hospital · Updated on 2025-06-03
320
Participants Needed
1
Research Sites
68 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive neuromodulation technique. Existing evidence suggested that taVNS improves pain management, sleep quality, inflammatory responses, and gastrointestinal recovery after surgery. This study is designed to test the hypothesis that perioperative use of taVNS may improve quality of recovery in patients after major noncardiac surgery.
CONDITIONS
Official Title
Transcutaneous Auricular Vagus Nerve Stimulation and Quality of Recovery After Major Noncardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older but younger than 85 years
- Scheduled for elective or limited-time noncardiac surgery with expected duration of 2 hours or more
You will not qualify if you...
- Lesions or infections of the auricle skin
- Recent or long-term use of cholinergic or anticholinergic medications
- Neurosurgery
- Expected mechanical ventilation with intubation for 1 day or more after surgery
- Diagnosed schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before surgery
- Preoperative left ventricular ejection fraction less than 30%, or presence of sick sinus syndrome, sinus bradycardia (heart rate less than 50 beats per minute), atrioventricular block of grade II or above, or implanted pacemaker
- Inability to communicate due to coma, severe dementia, or language barrier before surgery, or unable to cooperate with intervention
- American Society of Anesthesiologists physical status grade higher than IV, or estimated survival less than 24 hours
AI-Screening
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Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
H
Hong Hong, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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