Actively Recruiting
Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder
Led by VA Office of Research and Development · Updated on 2026-03-03
80
Participants Needed
1
Research Sites
266 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD). Veterans undergo brain imaging and physiological measures in conjunction with traumatic scripts before and after three months of twice daily treatment with tcVNS or sham stimulation at home.
CONDITIONS
Official Title
Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans between the ages of 18 and 75 with a diagnosis of PTSD based on DSM-5 criteria
You will not qualify if you...
- History of mild traumatic brain injury based on VA criteria
- Moderate or greater traumatic brain injury
- Positive pregnancy test
- Meningitis or other neurological disorder
- Alcohol or substance abuse disorder within the past 12 months based on DSM-5 criteria
- Current or lifetime history of schizophrenia, schizoaffective disorder, bipolar I disorder, anorexia nervosa, or bulimia based on DSM-5
- Active suicidal ideation with a plan
- History of serious medical or neurological illness that would prevent participation based on clinical judgment
- Active treatment with opiates or benzodiazepines
- History of structural brain abnormality on MRI or CT if previously performed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States, 30033-4004
Actively Recruiting
Research Team
D
Doug J Bremner, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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