Actively Recruiting

Phase Not Applicable
Age: 25Years - 64Years
All Genders
NCT06723743

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

Led by Baylor College of Medicine · Updated on 2026-05-07

30

Participants Needed

2

Research Sites

52 weeks

Total Duration

On this page

Sponsors

B

Baylor College of Medicine

Lead Sponsor

M

Michael E. DeBakey VA Medical Center

Collaborating Sponsor

AI-Summary

What this Trial Is About

This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and depression and/or posttraumatic stress disorder (PTSD). The study seeks to answer two main questions: 1. Can active taVNS improve attention and memory compared to sham (placebo) stimulation? 2. Does taVNS affect heart rate variability (HRV)? taVNS delivers a gentle electrical current to the vagus nerve through electrodes placed on the ear, targeting brain areas involved in attention and memory without requiring surgery. This study uses a crossover design, meaning all participants will experience two sessions: one with active taVNS and one with sham stimulation. The sham session feels similar but does not deliver actual stimulation, allowing researchers to compare the two and understand taVNS's effects on the brain. In a single visit, participants will: * Complete eligibility screening (questionnaires and vital signs). * Undergo two sessions (one active and one sham), randomly assigned. * Perform attention tasks before and after each session. * Have their heart rate monitored during the sessions. The findings will help determine whether taVNS could be an effective treatment for improving attention and memory in veterans with TBI.

CONDITIONS

Official Title

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

Who Can Participate

Age: 25Years - 64Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Ages 25 to 64 years
  • Right-handed
  • Veterans with deployment history to Operation Iraqi Freedom (OIF), Operation Enduring Freedom (OEF), Operation New Dawn (OND), or other post 9/11 war on terrorism
  • History of PTSD and/or depression
  • Military-related mild traumatic brain injury
  • Stable psychotropic medication use for at least 3 months if applicable
  • If taking stimulants, a washout period of at least 12 hours required
Not Eligible

You will not qualify if you...

  • History of neurological, cardiovascular, or pulmonary disease
  • Any type of cardiac arrhythmia
  • Active suicidal thoughts
  • Visible wounds on the skin of the left ear
  • Medical implants such as cardiac defibrillators, pacemakers, or deep brain stimulators
  • Pregnancy
  • Completed taVNS treatment within the past 4 weeks
  • Current substance use disorder (except mild cannabis use disorder)
  • Current moderate or severe alcohol use disorder
  • Major cognitive disorder

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Michael E. DeBakey VA Medical Center

Houston, Texas, United States, 77030

Actively Recruiting

2

Michael E. DeBakey VA Medical Center

Houston, Texas, United States, 77030

Actively Recruiting

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Research Team

L

Lane Witkowski Research Coordinator

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

TREATMENT

Number of Arms

2

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