Actively Recruiting

Phase 2
Age: 19Years - 45Years
FEMALE
NCT03875378

Transdermal Estrogen in Women With Anorexia Nervosa

Led by Pouneh K. Fazeli, MD · Updated on 2025-08-07

66

Participants Needed

1

Research Sites

435 weeks

Total Duration

On this page

Sponsors

P

Pouneh K. Fazeli, MD

Lead Sponsor

E

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Randomized, placebo-controlled study investigating the use of physiologic, transdermal estrogen for low bone mass in adult women with anorexia nervosa.

CONDITIONS

Official Title

Transdermal Estrogen in Women With Anorexia Nervosa

Who Can Participate

Age: 19Years - 45Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Female
  • Age between 19 and 45 years
  • Diagnosis of anorexia nervosa based on DSM-5 criteria
  • Weight less than 85% of ideal body weight
  • Amenorrhea (absence of menstrual periods)
  • Bone density T-score less than -1.0 at the spine or hip
Not Eligible

You will not qualify if you...

  • Diseases affecting bone metabolism such as untreated thyroid problems, vitamin D deficiency, Cushing's syndrome, diabetes, or kidney problems
  • History of blood clots
  • History of stroke or heart attack
  • Blood clotting disorders
  • Personal or first-degree relative history of breast cancer
  • History of hereditary angioedema
  • Use of medications affecting bone metabolism recently or within specific time frames
  • Bone fracture within the last 12 months
  • Abnormal blood test results including low potassium, high liver enzymes, low hemoglobin, or high triglycerides
  • Pregnant, breastfeeding, or planning pregnancy within 18 months
  • Active substance abuse
  • Elevated parathyroid hormone levels
  • Very low vitamin D levels
  • Low phosphorus levels

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

University of Pittsburgh School of Medicine

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

Loading map...

Research Team

P

Pouneh Fazeli, MD

CONTACT

S

Shari Reynolds

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Transdermal Estrogen in Women With Anorexia Nervosa | DecenTrialz