Actively Recruiting
Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
Led by Washington University School of Medicine · Updated on 2025-10-14
40
Participants Needed
1
Research Sites
157 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare buprenorphine patch for induction (starting) of buprenorphine in pregnant patients with opioid use disorder. The main questions it aims to answer are: 1. Is there a buprenorphine induction method that results in the least moderate-to-severe opioid withdrawal symptoms in pregnant patients with opioid use disorder? 2. Is there a buprenorphine induction method that results in a higher treatment success rate? Under normal circumstances, patients who are planning to start sublingual (under the tongue) buprenorphine for opioid use disorder must first go into withdrawal to start the medication safely. Study participants will be given a buprenorphine patch during the required withdrawal period before starting sublingual treatment, and be surveyed daily by phone to assess their withdrawal symptoms. They will also be followed at prenatal appointments to evaluate treatment success based on urine drug screen results. Researchers will compare patients receiving no buprenorphine patch according to the current standard care protocol.
CONDITIONS
Official Title
Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Viable pregnancy
- Meet diagnostic criteria for opioid use disorder
- Receive prenatal care through opioid use disorder specific clinic at our institution
- Opioid use within 24 hours prior to presentation
- Desire treatment with buprenorphine
You will not qualify if you...
- Patients already receiving treatment for opioid use disorder
- History of prior induction attempt with buprenorphine
- Active withdrawal at time of presentation
- Medical contraindication to buprenorphine
- Requiring immediate hospitalization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University in St. Louis
St Louis, Missouri, United States, 63124
Actively Recruiting
Research Team
C
Cassandra J Trammel, MD, MBA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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