Actively Recruiting
Transformative Research in Diabetic Nephropathy
Led by University of Pennsylvania · Updated on 2026-02-27
400
Participants Needed
17
Research Sites
547 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
M
MOUNT SINAI HOSPITAL
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (\> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol.
CONDITIONS
Official Title
Transformative Research in Diabetic Nephropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of type 1 or type 2 diabetes according to American Diabetes Association criteria
- Willingness to comply with study requirements including full participation in follow-up visits
- Ability to provide informed consent
- Adult participants
- Planned kidney biopsy prescribed by a nephrologist for medical reasons
You will not qualify if you...
- End-stage renal disease (chronic dialysis or kidney transplant)
- History of dialysis for more than 30 days before biopsy
- Institutionalized individuals
- Solid organ or bone marrow transplant recipient at time of first kidney biopsy
- Life expectancy less than 3 years
- History of active alcohol or substance abuse impairing compliance
- Unable to provide informed consent
- Active cancer requiring treatment, except non-melanoma skin cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 17 locations
1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
University of Southern California
Los Angeles, California, United States, 90033
Active, Not Recruiting
3
Stanford University
Palo Alto, California, United States
Actively Recruiting
4
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
5
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
6
University of Michigan
Ann Arbor, Michigan, United States, 48109
Active, Not Recruiting
7
University of New Mexico
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
8
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
9
Columbia University
New York, New York, United States, 10032
Active, Not Recruiting
10
Albert Einstein College of Medicine
The Bronx, New York, United States, 10461
Active, Not Recruiting
11
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
12
Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
13
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
14
Lehigh Valley Health Network
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
15
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
16
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
17
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
K
Katalin Susztak, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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