Actively Recruiting
Transformative Research in Diabetic Nephropathy 2.0
Led by University of Pennsylvania · Updated on 2026-03-02
200
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
G
GlaxoSmithKline
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, may affect the kidneys. People can join only if they are already having a kidney biopsy or kidney surgery as part of their regular medical care. The main questions this study aims to answer are: * Do people who take SGLT2 inhibitors show different biological patterns in kidney tissue than similar people who do not take them? * Are these kidney tissue patterns linked with how kidney health changes over time? Researchers will compare participants who take SGLT2 inhibitors with similar participants who do not take these medicines. Participants will: Let researchers use one stored slide of kidney tissue from their regular care (no extra research biopsy) Give a blood sample and a urine sample Let researchers review medical record information over time
CONDITIONS
Official Title
Transformative Research in Diabetic Nephropathy 2.0
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Estimated glomerular filtration rate (eGFR) of 10 ml/min/1.73 m2 or higher based on the 2021 race-free CKD-EPI equation
- Underwent a clinically indicated kidney biopsy, living donor biopsy, or nephrectomy with available non-tumor adjacent tissue
- Able and willing to provide informed consent for release of one pathology slide and clinical data abstraction
You will not qualify if you...
- Unable to provide informed consent
- Archived biopsy or surgical tissue unavailable for slide preparation
- Any local institutional policy that prohibits release of H&E slides for research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
G
Gaia Coppock, MD
CONTACT
M
Mohammed Al Dulaimee, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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