Actively Recruiting
A Translational Study for Locoregional Recurrence of T4 Colon Cancer
Led by National Taiwan University Hospital · Updated on 2025-05-25
60
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating T4 locally advanced colon cancer, which has poor outcomes when locoregional recurrence occurs. This study aims to understand why stage IIB/C colon cancer has worse outcomes than stage IIIA, despite similar treatments. The focus is on exploring cancer biology, metastatic mechanisms, and clinicopathology, particularly the role of peritoneal spreading as a metastatic route and the potential of serum epigenetic changes and cell-free DNA as prognostic markers. Participants will undergo radical or palliative colectomy, which aims to remove all identifiable tumors. The study will explore the role of cell-free DNA in ascites fluid as a biomarker for locoregional recurrence and investigate risk factors by comparing biomolecular markers from blood and ascites samples. This observational study follows patients after surgery to collect these data. During the study, researchers will measure and compare cell-free DNA levels and sequencing from ascites and serum over one year. Participants' clinical information and biomolecular data will be correlated to identify factors related to recurrence. The study's participation duration depends on follow-up, and no investigational drugs are given. The study is sponsored by National Taiwan University Hospital and aims to improve understanding of T4 colon cancer recurrence risks.
CONDITIONS
Brief Title
A Translational Study for Locoregional Recurrence of T4 Colon Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with colorectal cancer
- Have undergone or are planned to undergo radical or palliative colectomy, including minimally invasive or open surgery
You will not qualify if you...
- Under 18 years old
- Pregnant
- Receiving peritoneal dialysis
- Unwilling to undergo colorectal surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to 2 weeks
Participants undergo radical or palliative colectomy surgery for colorectal cancer.
1 surgery visit and approximately 1 post-operative visit
Duration - Up to 1 year
Participants are observed to monitor cell-free DNA levels and sequencing correlations between ascites and serum.
Periodic follow-up visits during the year
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital Hsin-Chu branch
Hsinchu, Taiwan, 308
Actively Recruiting
Research Team
Y
Yu-Tso Liao, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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