Study to Identify Molecular Types and Biomarkers in Chinese Patients With Non-Cystic Fibrosis Bronchiectasis and Healthy Adults

What this Trial Is About

Non-cystic fibrosis bronchiectasis NCFBE is a chronic lung disease marked by persistent cough with mucus and repeated lung infections, caused by permanent widening of the airways. This condition is increasingly common worldwide and poses significant health and economic challenges. Chinese patients with NCFBE show different clinical features compared to Western patients, including more frequent hospitalizations and different infection patterns, but the underlying biological causes remain unclear. This study will observe and analyze Chinese NCFBE patients and healthy adults using biomarker tests and advanced molecular analyses to explore how disease pathways relate to symptoms and uncover distinct molecular types behind clinical presentations. The study includes a group of healthy controls aged 30 or older and up to 300 NCFBE patients aged 18 or older, with about 30% having had at least two lung flare-ups in the past year. Healthy participants will be assessed mainly at the start and optionally with bronchoscopy, while patients will have baseline, 6-month, 12-month, and additional visits during flare-ups. Participants will attend scheduled visits for clinical assessments, lung function tests, imaging, sputum microbiology, and questionnaires over 12 months. Data collected include lung function measures, imaging results, gene expression, symptom scores, and medical history to help identify disease patterns. The study also allows phone visits for some follow-ups and tracks flare-up events and hospitalizations to better understand disease progression and patient outcomes.

A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBE