Study to Identify Biomarkers and Patient Types in COPD and Pre-COPD for Personalized Treatments in Chinese Adults

What this Trial Is About

Researchers are conducting an observational study to better understand the progression of lung function decline, inflammatory and immune mechanisms in people with pre-COPD or preserved ratio impaired spirometry PRISm, as well as clinical outcomes and subtypes related to physician-diagnosed COPD. The study will follow participants for one year to gather detailed information on these aspects. The study includes several groups healthy controls aged 30 or older individuals aged 30 to 50 with respiratory symptoms or lung abnormalities but without airflow obstruction pre-COPD or PRISm mild COPD patients split into two cohorts based on age 30-50 and over 50 and participants aged 50 or older with moderate to very severe COPD. Each group is observed without treatment interventions, focusing on clinical features and biomarkers. Participants will provide medical, occupational, and family history and undergo lung function tests and questionnaires at the start and throughout the 56-week study. Researchers will monitor lung function measures, inflammation markers, respiratory symptoms, medication use, and other biological tests. This comprehensive monitoring aims to identify patient subtypes and support future personalized COPD treatments.

A Translational Study for Prediction of Biomarkers and Identification of Phenotype and Endotype of COPD and Pre-COPD Outcomes in Chinese Population