Study of Lung Injury Over Time in Children and Young Adults Undergoing Hematopoietic Stem Cell Transplant

What this Trial Is About

Researchers are studying lung injury in children and young adults who receive hematopoietic stem cell transplants HSCT. This study aims to better understand lung complications such as diffuse alveolar hemorrhage, thrombotic microangiopathy, interstitial pneumonitis, and bronchiolitis obliterans that affect many patients after HSCT. Since HSCT is increasingly used for non-cancer conditions like sickle cell disease, improving diagnosis and treatment of lung problems is important to reduce illness and death. This is a prospective, multi-center observational study involving pediatric and young adult patients undergoing allogeneic or autologous HSCT. The study collects biological samples and uniformly screens participants over time to identify causes of lung injury and evaluate new diagnostic methods and treatments. Participants are followed for lung injury incidence up to 24 months after their transplant. During the study, participants undergo regular assessments to monitor lung health. Researchers collect data on lung injury occurrence and progression, aiming to understand and improve outcomes after HSCT. The primary measurement is the incidence of lung injury within two years following transplant. The study runs from September 2021 to September 2033, providing long-term observation of lung complications in this population.

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients