Actively Recruiting
Transthoracic vs Transbronchial Cryoablation for Early-stage Peripheral Lung Cancer
Led by Jiayuan Sun · Updated on 2025-07-18
110
Participants Needed
5
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to compare the efficacy and safety of transthoracic cryoablation to transbronchial cryoablation in the treatment of early-stage peripheral lung cancer.
CONDITIONS
Official Title
Transthoracic vs Transbronchial Cryoablation for Early-stage Peripheral Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age older than 18 years
- Primary peripheral lung cancer diagnosed by pathology and clinical stage T1N0M0 or stage IA
- Target lesion suitable for both CT and bronchoscopy-guided ablation
- Not suitable for surgery or refuse surgery, agree to initial ablation therapy and sign informed consent
You will not qualify if you...
- Platelet count less than 70×10⁹/L, severe bleeding tendency, or coagulation dysfunction not correctable in short term
- Severe pulmonary fibrosis or pulmonary arterial hypertension
- Infectious or radioactive inflammation around lesion, uncontrolled skin infection at puncture site, systemic infection, or fever over 38.5°C
- Severe insufficiency of liver, kidney, heart, lung, or brain; severe anemia, dehydration, or serious nutritional disorders not correctable in short term
- Poorly controlled malignant pleural effusions
- Anticoagulation or anti-platelet drugs (except certain new oral anticoagulants) not stopped at least 5 to 7 days before ablation
- Eastern Cooperative Oncology Group (ECOG) score greater than 2
- Other tumors with extensive metastases and expected survival less than 6 months
- Episodic psychosis
- Pregnancy or planning pregnancy during study
- Participation in other clinical trials within 30 days
- Any condition investigator deems inappropriate for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China, 510120
Not Yet Recruiting
2
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 462000
Not Yet Recruiting
3
Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Actively Recruiting
4
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Not Yet Recruiting
5
Sir Run Run Shaw Hospital , affiliated with the Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Not Yet Recruiting
Research Team
J
Jiayuan Sun, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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