Actively Recruiting
Transthoracic vs Transbronchial Radiofrequency Ablation for Lung Cancer
Led by Shanghai Chest Hospital · Updated on 2026-04-13
110
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
Sponsors
S
Shanghai Chest Hospital
Lead Sponsor
S
Sir Run Run Shaw Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to investigate the efficacy and safety of transthoracic versus transbronchial ablation in the treatment of early stage peripheral lung cancer.
CONDITIONS
Official Title
Transthoracic vs Transbronchial Radiofrequency Ablation for Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years
- Diagnosed with primary peripheral lung cancer stage IA (T1N0M0) confirmed by pathology and staging
- Lesion suitable for both CT-guided and bronchoscopy-guided ablation
- Unsuitable for surgery or refusal of surgery and provided signed informed consent for initial ablation therapy
You will not qualify if you...
- Platelet count below 50×10⁹/L or severe bleeding and coagulation problems not correctable quickly
- Severe pulmonary fibrosis or pulmonary arterial hypertension
- Infectious or radioactive inflammation near the lesion, uncontrolled skin infection at puncture site, systemic infection, or fever above 38.5°C
- Severe liver, kidney, heart, lung, or brain failure; severe anemia; dehydration; or serious metabolic disorders not quickly treatable
- Poorly controlled malignant pleural effusions
- Anticoagulation or anti-platelet drugs not stopped 5 to 7 days before ablation (except certain new oral anticoagulants)
- Eastern Cooperative Oncology Group (ECOG) score over 2
- Other tumors with extensive metastasis and life expectancy under 6 months
- Episodic psychosis
- Implanted electronic devices such as pacemakers or defibrillators
- Pregnant or planning pregnancy during the study
- Participation in other clinical studies within the last 30 days
- Any other condition deemed unsuitable by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
J
Jiayuan Sun, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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