Actively Recruiting
Transversus Abdominis Plane Block Versus Wound Infiltration for Pulmonary Function Preservation Following Laparoscopic Living Donor Nephrectomy
Led by Rabin Medical Center · Updated on 2026-01-07
80
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study compares two pain control techniques in patients undergoing laparoscopic kidney donation surgery: transversus abdominis plane (TAP) block versus wound infiltration with local anesthetic. Postoperative pain can impair breathing by causing patients to take shallow breaths to avoid discomfort. This study will evaluate which technique better preserves lung function, specifically peak expiratory flow (PEF), after surgery. Eighty patients will be randomly assigned to receive either a TAP block (injection of local anesthetic into the abdominal wall muscles before surgery) or wound infiltration (injection of local anesthetic at the incision sites at the end of surgery). Both patients and the staff measuring outcomes will be blinded to group assignment. The primary outcome is the percentage change in PEF from before surgery to discharge from the recovery room. Secondary outcomes include pain scores, opioid use, breathing complications, and length of hospital stay.
CONDITIONS
Official Title
Transversus Abdominis Plane Block Versus Wound Infiltration for Pulmonary Function Preservation Following Laparoscopic Living Donor Nephrectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients scheduled for elective laparoscopic living donor nephrectomy (LLDN)
- Age greater than 18 years
- Body mass index (BMI) between 20 and 40 kg/m2
- Able and eligible to provide informed consent
You will not qualify if you...
- Undergoing open or hand-assisted surgery instead of laparoscopic
- Known cardiac or pulmonary disease
- Presence of chronic pain conditions like fibromyalgia or neuropathic pain
- Contraindications to regional anesthesia such as allergy to local anesthetics or skin lesions at injection sites
- Allergic to any components of multimodal analgesia including opioids, paracetamol, tramadol, or dipyrone
- Severe preexisting lung disease (e.g., obstructive lung disease with FEV1 below 49%, restrictive lung disease with FVC below 49%, or pulmonary hypertension)
- Intraoperative bleeding needing transfusion of more than three units of blood products
- Hemodynamic instability requiring postoperative vasopressor or inotropic support
- Need for conversion to open surgery
- Requirement of mechanical ventilation after surgery in the recovery unit
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rabin Medical Center, Beilinson Hospital
Petah Tikva, Israel
Actively Recruiting
Research Team
K
Karam Azem, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here