Actively Recruiting
Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure
Led by Veterans Medical Research Foundation · Updated on 2025-04-22
158
Participants Needed
3
Research Sites
139 weeks
Total Duration
On this page
Sponsors
V
Veterans Medical Research Foundation
Lead Sponsor
U
University of Minnesota
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if receiving Trauma-Informed Guilt Reduction (TrIGR) Therapy is as effective as receiving Prolonged Exposure Therapy among veterans with PTSD and trauma related guilt. The main questions it aims to answer are: Will TrIGR be comparable to PE in terms of PTSD symptom reduction? Will it TrIGR be comparable to PE in improving functioning and reducing depression symptoms? Will it be superior in improving trauma-related guilt and shame?
CONDITIONS
Official Title
Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- U.S. Veterans age 18 or older who served since Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF)
- Diagnosed with post-traumatic stress disorder (PTSD)
- Experience trauma-related guilt with a score of 2 or higher on feeling trauma-related guilt much or all of the time or a score of 3 or higher on at least one guilt cognition factor on the Trauma Related Guilt Inventory
- Not currently receiving trauma-focused treatments such as Prolonged Exposure (PE) or Cognitive Processing Therapy (CPT)
- Willingness to attend psychotherapy and assessment sessions
You will not qualify if you...
- Current risk of suicidal or homicidal behavior requiring immediate intervention
- Current severe substance use disorder within the past two months based on DSM-5 criteria
- Current unmanaged psychosis or mania
- Life threatening or unstable medical illness
- Inability to read
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Little Rock Veterans Health Care System (LRVHCS)
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
Southeast Louisiana Veterans Health Care System (SLVHCS)
New Orleans, Louisiana, United States, 70119
Actively Recruiting
3
William S. Middleton Memorial Hospital
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
S
Sonya Norman, PhD
CONTACT
K
Kaitlyn Panza, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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