Actively Recruiting
Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow
Led by University of California, Irvine · Updated on 2026-05-04
10
Participants Needed
1
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a phase I/II protocol investigating whether Nelfinavir can improve anemia and lower serum fibrosis biomarkers in Myelofibrosis patients.
CONDITIONS
Official Title
Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Diagnosed with myelofibrosis according to the 2016 WHO criteria
- Hemoglobin level 10 gm/dL or less at screening
- Serum ferritin 100 or higher
- May continue current MPN treatments including aspirin, hydroxyurea, interferon-alpha, ruxolitinib, fedratinib, or anagrelide
- Peripheral blast count less than 10% during screening
- Free of other active or metastatic cancers except localized skin cancer
- Able to undergo blood draws and symptom assessments
- Agree to use effective contraception during the study and for 60 days after last dose
You will not qualify if you...
- Eastern Cooperative Oncology Group (ECOG) score of 3 or higher
- Currently pregnant or planning pregnancy during the study
- Taking Momelotinib or Pacritinib
- Taking any medications contraindicated with Nelfinavir
- Currently breastfeeding
- Known uncontrolled active viral or bacterial infection
- Known HIV positive
- Significant major organ or blood function impairment including:
- Serum creatinine clearance less than 30 ml/min (eGFR)
- Bilirubin over 1.5 mg/dl except Gilbert's disease, or ALT/AST over twice the normal limit, or liver cirrhosis seen on imaging
- Platelet count below 50 x 10^9/L without transfusions
- Absolute neutrophil count below 0.75 x 10^9/L without growth factors
- Known allergy to Nelfinavir
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chao Family Comprehensive Cancer Center, University of California, Irvine
Orange, California, United States, 92868
Actively Recruiting
Research Team
C
Chao Family Comprehensive Cancer Center University of California, Irvine
CONTACT
U
University of California Irvine Medical
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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