Actively Recruiting
Treatment of ACuTe Coronary Syndromes With Low-dose colchICine
Led by Beijing Anzhen Hospital · Updated on 2024-10-30
6574
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial is designed to evaluate whether low-dose colchicine, in addition to standard treatment recommended by guidelines, further reduces the risk of major adverse cardiovascular events in patients with acute coronary syndromes (ACS) through a prospective, randomized, double-blind, placebo-controlled clinical trial.
CONDITIONS
Official Title
Treatment of ACuTe Coronary Syndromes With Low-dose colchICine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age ≥ 18 years
- Definite diagnosis of acute coronary syndrome
- Ability and willingness to provide written informed consent
You will not qualify if you...
- Type 2 myocardial infarction
- Valvular heart disease likely to require surgery
- History of non-skin cancer in past 3 years
- Inflammatory bowel disease or chronic diarrhea
- History of gastric ulcer or previous gastric bleeding
- Neuromuscular diseases or elevated creatine kinase levels (>3 times normal)
- Significant blood abnormalities (low hemoglobin, abnormal hematocrit, low white blood cell or platelet counts)
- Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2
- Severe liver disease with coagulation disorders or elevated liver enzymes and bilirubin
- Cognitive decline affecting daily living activities
- Drug or alcohol abuse
- Existing or planned immunosuppressive therapies
- Need for long-term colchicine treatment due to other causes
- Known or suspected allergy to colchicine
- Use of strong CYP3A4 or P-glycoprotein inhibitors without alternatives
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China, 100029
Actively Recruiting
Research Team
Y
Yujie Zhou, PhD, MD
CONTACT
X
Xiaoteng Ma, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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