Actively Recruiting
Treatment of ADHD Using High and Low Frequency Paired Associative Deep Transcranial Magnetic Stimulation
Led by Ben-Gurion University of the Negev · Updated on 2025-08-06
90
Participants Needed
1
Research Sites
267 weeks
Total Duration
On this page
Sponsors
B
Ben-Gurion University of the Negev
Lead Sponsor
S
Soroka University Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study investigates the effects of high and low-frequency paired associative deep transcranial magnetic stimulation (dTMS) on adults with Attention Deficit Hyperactivity Disorder (ADHD). The study aims to explore whether targeting the prefrontal cortex with paired stimulation can improve symptoms of ADHD by balancing cortical arousal between the brain hemispheres. A total of 90 participants with ADHD will be recruited. Participants with ADHD will undergo three weeks of daily TMS treatment, while participants who receive a sham treatment will be included for baseline comparisons. The study will measure electrophysiological, cognitive, and clinical outcomes using a variety of assessments, including EEG, cognitive tests, and CAARS to evaluate the treatment's efficacy.
CONDITIONS
Official Title
Treatment of ADHD Using High and Low Frequency Paired Associative Deep Transcranial Magnetic Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged 21-65.
- Diagnosed with ADHD according to DSM-5 criteria.
- Willing to take Ritalin IR 10mg starting one week before treatment until the end, with specified timing rules.
- Able to provide written and oral consent to participate in the study.
You will not qualify if you...
- Having other active psychiatric disorders listed in DSM-5 Axis I.
- Currently on antipsychotic treatment, antidepressants, or mood stabilizers.
- History of intolerance to transcranial magnetic stimulation (TMS).
- Diagnosed with severe personality disorder per DSM-5.
- Current suicidal tendencies.
- High and uncontrolled blood pressure.
- History of epilepsy, seizures, or febrile seizures.
- Family history of epilepsy or seizures in first degree relatives.
- History of head injury or major stroke causing impairment.
- Presence of metal in the head (outside oral cavity) or history of related surgeries or implants.
- Use of pacemakers, hearing aids, neurostimulators, or medical pumps.
- History of drug or alcohol addiction.
- Inability to communicate adequately with the examiner.
- Participation in another medical study within 3 months prior.
- Inability to sign consent form.
- Pregnancy or unwillingness to avoid pregnancy and use contraception during the study.
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Trial Site Locations
Total: 1 location
1
Ben Gurion University of the Negev
Beersheba, Israel
Actively Recruiting
Research Team
A
Abraham Zangen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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