Pilot Study of Low-Dose Aspirin Treatment After Preeclampsia to Improve Blood Vessel Health and Blood Pressure in Postpartum Women

What this Trial Is About

Researchers are evaluating the use of low-dose aspirin to support vascular recovery during the early postpartum period in individuals who experienced preeclampsia. This pilot study aims to test the feasibility of conducting a randomized controlled trial comparing low-dose aspirin to a placebo and to assess the effects of aspirin on blood vessel function and blood pressure. The study plans to enroll up to 60 adult postpartum individuals diagnosed with preeclampsia. Participants will be randomly assigned to receive either an 81 mg aspirin pill or an identical placebo pill daily for six months after delivery. Both groups will monitor their blood pressure at home and attend two study visits where blood draws, blood pressure measurements, and endothelial function tests using microiontophoresis will be performed. Adherence to the study treatment is tracked through pill counts, text message check-ins, patient diaries, and biochemical monitoring. During the study, participants will have three visits involving blood pressure measurements, blood draws, questionnaires, and endothelial function assessments. Researchers will monitor blood pressure changes, medication use, endothelial function, and other cardiovascular measures from delivery through six months postpartum. The main outcome is the percentage of participants who are eligible, enrolled, and retained in the study. Safety and adherence will be regularly evaluated throughout the trials duration.

Treatment With Aspirin After Preeclampsia: TAP Trial