Actively Recruiting
Treatment With Aspirin After Preeclampsia: TAP Trial
Led by Malamo Countouris · Updated on 2026-06-04
60
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
M
Malamo Countouris
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of low-dose aspirin to support vascular recovery during the early postpartum period in individuals who experienced preeclampsia. This pilot study aims to test the feasibility of conducting a randomized controlled trial comparing low-dose aspirin to a placebo and to assess the effects of aspirin on blood vessel function and blood pressure. The study plans to enroll up to 60 adult postpartum individuals diagnosed with preeclampsia. Participants will be randomly assigned to receive either an 81 mg aspirin pill or an identical placebo pill daily for six months after delivery. Both groups will monitor their blood pressure at home and attend two study visits where blood draws, blood pressure measurements, and endothelial function tests using microiontophoresis will be performed. Adherence to the study treatment is tracked through pill counts, text message check-ins, patient diaries, and biochemical monitoring. During the study, participants will have three visits involving blood pressure measurements, blood draws, questionnaires, and endothelial function assessments. Researchers will monitor blood pressure changes, medication use, endothelial function, and other cardiovascular measures from delivery through six months postpartum. The main outcome is the percentage of participants who are eligible, enrolled, and retained in the study. Safety and adherence will be regularly evaluated throughout the trial's duration.
CONDITIONS
Brief Title
Treatment With Aspirin After Preeclampsia: TAP Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postpartum individuals 18 years or older
- Diagnosis of preeclampsia
You will not qualify if you...
- Fetal anomaly
- Multiple gestation pregnancy
- History of pre-pregnancy hypertension
- Allergy or contraindication to low-dose aspirin
- History of pre-pregnancy diabetes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Screening and enrollment visit
Duration - 6 months
Participants take a daily low-dose aspirin pill or placebo for six months postpartum while monitoring home blood pressure and adherence.
2 study visits during treatment
Trial Site Locations
Total: 1 location
1
University of Pittsburgh Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
A
Alisse K Hauspurg, MD
S
Sila Yavan, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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