Actively Recruiting
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
Led by University of Twente · Updated on 2025-05-16
150
Participants Needed
20
Research Sites
294 weeks
Total Duration
On this page
Sponsors
U
University of Twente
Lead Sponsor
E
Erasme University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest. The main questions the trial aims to answer are: * Does ESE treatment improve outcome? * What is the impact of ESE treatment on healthcare costs? Participants in the the intervention group will receive standard care completed with anti-seizure treatment. The control group will receive standard care without anti-seizure treatment.
CONDITIONS
Official Title
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Coma (Glasgow Coma Scale score 64 8) after out of hospital cardiac arrest and resuscitation
- Age 65 18 years
- Continuous EEG with at least eight electrodes started < 24h after return of spontaneous circulation (ROSC)
- Electrographic status epilepticus (ESE) or possible ESE according to Salzburg and ACNS criteria
- Possibility to start treatment within three hours after detection of ESE
You will not qualify if you...
- Known history of another medical condition with limited life expectancy (< six months)
- Any progressive brain illness, such as a brain tumor or neurodegenerative disease
- Pre-admission Glasgow Outcome Scale score of 3 or lower
- Reason other than the neurological condition to withdraw treatment
- EEG background activity prior to the emergence of ESE indicative of extensive irreversible anoxic brain injury
- Follow-up impossible due to logistic reasons, for example not living in the Netherlands or Belgium
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 20 locations
1
Centre Hospitalier Universitaire Saint-Pierre
Brussels, Belgium
Not Yet Recruiting
2
Hôpital Universitaire de Bruxelles
Brussels, Belgium
Not Yet Recruiting
3
Universitair Ziekenhuis Brussel
Brussels, Belgium
Not Yet Recruiting
4
Centre Hospitalier Universitaire Marie Curie
Charleroi, Belgium
Not Yet Recruiting
5
Ziekenhuis Oost-Limburg
Genk, Belgium
Not Yet Recruiting
6
Universitair Ziekenhuis Gent
Ghent, Belgium
Not Yet Recruiting
7
Centre Hospitalier Chrétien - MontLégia
Liège, Belgium
Not Yet Recruiting
8
Centre Hospitalier Universitaire Sart-Tilmant
Liège, Belgium
Not Yet Recruiting
9
Amsterdam University Medical Center
Amsterdam, Netherlands
Not Yet Recruiting
10
Rijnstate Hospital
Arnhem, Netherlands
Actively Recruiting
11
Catharina Hospital
Eindhoven, Netherlands
Not Yet Recruiting
12
Medical Spectrum Twente
Enschede, Netherlands
Actively Recruiting
13
University Medical Center Groningen
Groningen, Netherlands
Not Yet Recruiting
14
Leiden University Medical Center
Leiden, Netherlands
Not Yet Recruiting
15
St. Antonius Hospital
Nieuwegein, Netherlands
Actively Recruiting
16
Canisius Wilhelmina Hospital
Nijmegen, Netherlands
Not Yet Recruiting
17
Radboud University Medical Center
Nijmegen, Netherlands
Actively Recruiting
18
Erasmus University Medical Center
Rotterdam, Netherlands
Actively Recruiting
19
Maasstad Hospital
Rotterdam, Netherlands
Not Yet Recruiting
20
VieCuri Medical Center
Venlo, Netherlands
Not Yet Recruiting
Research Team
J
Jeannette Hofmeijer, MD
CONTACT
N
Nicolas Gaspard, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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