Actively Recruiting
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
Led by University of Cincinnati · Updated on 2026-04-15
1060
Participants Needed
25
Research Sites
230 weeks
Total Duration
On this page
Sponsors
U
University of Cincinnati
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.
CONDITIONS
Official Title
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older
- Moderate-to-severe pre-stroke disability defined as modified Rankin Score 3-4 for at least 3 months before stroke
- Presenting to hospital within 24 hours of last known well time
- Diagnosis of acute ischemic stroke
- Blockage in internal carotid artery or M1 or dominant M2 segments of middle cerebral artery seen on CT or MR angiogram
- Presenting CT ASPECT score 3 or higher or MRI ASPECT score 4 or higher
- Presenting NIH Stroke Scale score 6 or higher
- Informed consent from patient if competent or legally authorized representative
You will not qualify if you...
- Known diagnosis of terminal cancer or terminal illness at time of stroke
- Unable to perform pre-stroke functional status assessment during hospital stay
- Pre-stroke disability considered temporary by investigator (e.g., recovering from illness or injury)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 25 locations
1
HonorHealth
Phoenix, Arizona, United States, 85013
Actively Recruiting
2
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States, 90027
Actively Recruiting
3
University of California at Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
4
Standford
Palo Alto, California, United States, 94305
Actively Recruiting
5
University of Cincinnati San Diego
San Diego, California, United States, 92121
Actively Recruiting
6
Swedish Medical Center
Englewood, Colorado, United States, 80113
Actively Recruiting
7
Hartford Health Hospital
Hartford, Connecticut, United States, 06106
Actively Recruiting
8
Yale University
New Haven, Connecticut, United States, 06510
Actively Recruiting
9
University of Miami
Miami, Florida, United States, 33125
Actively Recruiting
10
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
11
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
12
University of Louisville
Louisville, Kentucky, United States, 40202
Actively Recruiting
13
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
14
Barnes Jewish Hospital
Saint Loius, Missouri, United States, 63110
Actively Recruiting
15
New York University
Brooklyn, New York, United States, 11220
Actively Recruiting
16
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
17
Columbia University
New York, New York, United States, 10032
Actively Recruiting
18
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45219
Actively Recruiting
19
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
20
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
21
Baptist Memorial Hospital
Memphis, Tennessee, United States, 38120
Actively Recruiting
22
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
23
University of Texas at Austin
Austin, Texas, United States, 78712
Actively Recruiting
24
University of Washington
Seattle, Washington, United States, 98104
Actively Recruiting
25
West Virginia University
Morgantown, West Virginia, United States, 26506
Actively Recruiting
Research Team
E
Eva Mistry, MD
CONTACT
N
Naima Griffin
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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