Actively Recruiting
Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial
Led by Fundación EPIC · Updated on 2026-01-29
600
Participants Needed
49
Research Sites
304 weeks
Total Duration
On this page
Sponsors
F
Fundación EPIC
Lead Sponsor
A
Abbott
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims to compare a preventive percutaneous coronary intervention (PCI) plus optimal medical treatment (OMT) strategy vs. OMT for treatment of non-functionally significant non-culprit lesions presenting with optical coherence tomography (OCT) findings indicative of vulnerable plaque, in patients with ST-elevation myocardial infarction (STEMI) and multivessel disease.
CONDITIONS
Official Title
Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old
- Successful revascularization of culprit lesion after ST-elevation myocardial infarction within 72 hours of symptom onset
- Multivessel coronary disease with non-culprit lesions showing 40 to 69% diameter stenosis planned for FFR-guided revascularization between 24 hours and 60 days after PCI
- Non-culprit lesions suitable for pressure wire and OCT assessment and treatable with a single 2.0 to 4.5 mm everolimus-eluting stent
- Agreement to avoid participation in other clinical trials for 4 years after inclusion
- Signed informed consent
You will not qualify if you...
- Unable to provide informed consent
- Female of childbearing potential under 50 years without tubal ligation, ovariectomy, or hysterectomy
- Known intolerance to aspirin, heparin, everolimus, or contrast material
- Unresolved mechanical complication or cardiogenic shock at staged procedure
- Non-culprit lesions in left main coronary artery, vessels with prior revascularization, or with distal vessel occlusion
- Lesions unsuitable for single everolimus-eluting stent implantation due to length, bifurcation, angulation, or calcification
- History of asthma or bronchial hyper-reactivity
- Chronic kidney dysfunction with creatinine clearance below 45 ml/min
- Severe comorbidities limiting life expectancy to less than 4 years
- Currently enrolled in another clinical trial that has not completed its primary endpoint
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 49 locations
1
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain, 08907
Actively Recruiting
2
Hospital Universitario A Coruña
A Coruña, Spain, 15006
Actively Recruiting
3
Hospital General Universitario de Albacete
Albacete, Spain, 02006
Actively Recruiting
4
Hospital General Universitario Dr.Balmis
Alicante, Spain, 03010
Actively Recruiting
5
Hospital Universitari Sant Joan D'Alacant
Alicante, Spain, 03550
Actively Recruiting
6
Hospital Universitari Germans Trias I Pujol
Badalona, Spain, 08916
Actively Recruiting
7
Hospital Del Mar
Barcelona, Spain, 08003
Actively Recruiting
8
Hospital de Santa Creu I Sant Pau
Barcelona, Spain, 08025
Actively Recruiting
9
Hospital Universitari Vall Hebron
Barcelona, Spain, 08035
Actively Recruiting
10
Hospital Clinic de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
11
Hospital Universitario Puerta Del Mar
Cadiz, Spain, 11009
Actively Recruiting
12
Hospital General Universitario de Castellón
Castellon, Spain, 12004
Actively Recruiting
13
Hospital General Universitario de Ciudad Real
Ciudad Real, Spain, 13005
Actively Recruiting
14
Hospital Universitario Reina Sofia de Cordoba
Córdoba, Spain, 14004
Actively Recruiting
15
Hospital General Universitario de Elche
Elche, Spain, 03203
Actively Recruiting
16
Hospital Universitario de Cabueñes
Gijón, Spain, 33394
Actively Recruiting
17
Hospital Universitario de Girona Dr Trueta
Girona, Spain, 17007
Actively Recruiting
18
Hospital Universitario San Cecilio
Granada, Spain, 18016
Actively Recruiting
19
Chu de Toledo
Guadalajara, Spain
Actively Recruiting
20
Hospital Universitario Juan Ramon Jimenez
Huelva, Spain, 21005
Actively Recruiting
21
H.U. de Gran Canaria-Dr. Negrin
Las Palmas de Gran Canaria, Spain, 35010
Actively Recruiting
22
H.I.U. Materno Infantil de Las Palmas
Las Palmas de Gran Canaria, Spain, 35016
Actively Recruiting
23
Hospital Universitario de Leon
León, Spain, 24001
Actively Recruiting
24
Hospital La Princesa
Madrid, Spain, 28006
Actively Recruiting
25
Hospital Universitario Gregorio Marañon
Madrid, Spain, 28007
Actively Recruiting
26
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
27
Hospital Universitario Puerta de Hierro
Majadahonda, Spain, 28222
Actively Recruiting
28
Hospital de Manises
Manises, Spain, 46940
Actively Recruiting
29
Hospital de Merida
Mérida, Spain, 06800
Actively Recruiting
30
Hospital Universitario Virgen Arrixaca
Murcia, Spain, 30120
Actively Recruiting
31
Hospital Universitario Central de Asturias
Oviedo, Spain, 33011
Actively Recruiting
32
Hospital Universitari Son Espases
Palma de Mallorca, Spain, 07120
Actively Recruiting
33
Hospital Universitario de Navarra
Pamplona, Spain, 31008
Actively Recruiting
34
Hospital Clinico Universitario de Salamanca
Salamanca, Spain, 37007
Actively Recruiting
35
Hospital Universitario de Donostia
San Sebastián, Spain, 20014
Actively Recruiting
36
Hospital Universitario Nuestra Señora de La Candelaria
Santa Cruz de Tenerife, Spain, 38010
Actively Recruiting
37
Hospital Universitario Marqués de Valdecilla
Santander, Spain, 39008
Actively Recruiting
38
Hospital Clinico Universitario de Santiago de Compostela
Santiago de Compostela, Spain, 15706
Actively Recruiting
39
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
40
Hospital Universitari Joan Xxiii
Tarragona, Spain, 43005
Actively Recruiting
41
Hospital Universitari MútuaTerrassa
Terrassa, Spain, 08221
Actively Recruiting
42
Hospital Universitario de Torrevieja
Torrevieja, Spain, 03186
Actively Recruiting
43
Hospital Universitario 12 Octubre
Usera, Spain, 28041
Actively Recruiting
44
Hospital Clinico Universitario de Valencia
Valencia, Spain, 46010
Actively Recruiting
45
Hospital General Universitario de Valencia
Valencia, Spain, 46014
Actively Recruiting
46
Hospital Universitari I Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
47
Hospital Clínico Universitario de Valladolid
Valladolid, Spain, 47003
Actively Recruiting
48
Hospital Clinico Universitario Lozano Blesa
Zaragoza, Spain, 50009
Actively Recruiting
49
Hospital Universitari Miquel Servet
Zaragoza, Spain, 50009
Actively Recruiting
Research Team
J
Josep Gomez-Lara, MD, PhD
CONTACT
F
FUNDACION EPIC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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