Actively Recruiting
Treatment With Indapamide in Patients With Post-Surgical Hypoparathyroidism
Led by Lars Rejnmark · Updated on 2025-08-11
24
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to investigate the effect of daily treatment with Indapamide for 14 days on urinary calcium excretion in patients with post surgical hypoparathyroidisme.
CONDITIONS
Official Title
Treatment With Indapamide in Patients With Post-Surgical Hypoparathyroidism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Chronic post-surgical hypoparathyroidism diagnosed more than 1 year ago
- Require treatment with active vitamin D at a dose of at least 1 microgram per day
- Ionized plasma calcium between 1.15 and 1.25 mmol/L
- 25(OH)D vitamin level at least 50 nmol/L
- Plasma magnesium greater than 0.65 mmol/L
- Able to read and understand Danish
- Willing and able to sign the informed consent form
You will not qualify if you...
- Estimated glomerular filtration rate (eGFR) below 30 ml/min/1.73 m2
- Active cancer or cancer treatment within the past year, except thyroid or basal cell skin cancer
- Pregnancy, planning pregnancy, or breastfeeding within the past year
- Symptomatic low blood pressure or systolic blood pressure below 100 mmHg at screening
- Plasma potassium below 3.5 mmol/L
- Current diseases affecting calcium metabolism such as recent prolonged immobility, untreated diabetes (HbA1c > 53 mmol/mol), severe liver disease or hepatic encephalopathy, untreated thyroid disease
- Diseases affecting gastrointestinal absorption
- Use of lithium or diuretics within 4 weeks before treatment start
- Known allergy or sensitivity to Indapamide, its ingredients, or sulfonamides
- Known galactosemia, lactase deficiency, or glucose-galactose malabsorption
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Endocrinology and Internal Medicine
Aarhus, Denmark, 8200
Actively Recruiting
Research Team
S
Sarah Thornhøj, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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