Actively Recruiting
Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts
Led by Saglik Bilimleri Universitesi · Updated on 2025-09-08
16
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce "sticky bone," and bone gain can have a positive effect on intrabony defects frequently seen in periodontal disease, compared to grafts alone. This study aims to clinically and radiographically evaluate the effectiveness of using bovine-derived xenogenic bone grafts in combination with i-PRF and bovine-derived xenogeneic bone grafts alone in patients with intrabony defects and stage III periodontitis.
CONDITIONS
Official Title
Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients aged 18-65 years
- Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification
- Probing pocket depth of 5 mm or more persisting 6 weeks after initial periodontal treatment
- Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least 3 mm
- Non-smokers or those who smoke up to 10 cigarettes per day
You will not qualify if you...
- Patients younger than 18 or older than 65 years
- Patients unable to provide consent
- Presence of systemic diseases affecting surgery success, such as uncontrolled diabetes
- Single-walled intrabony defects
- Use of antibiotics, anti-inflammatory, immunosuppressive drugs, or birth control pills within the past 3 months
- Active periodontal treatment within the last 6 months or periodontal surgery within the last year
- Smoking more than 10 cigarettes per day
- Pregnancy or breastfeeding
- Use of medications affecting gums (e.g., calcium channel blockers, phenytoin, cyclosporine)
- Teeth with furcation defects
- Undergoing active orthodontic treatment
- Allergy to study biomaterials or prescribed medications
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sağlık Bilimleri Üniversitesi
Istanbul, Üsküdar, Turkey (Türkiye)
Actively Recruiting
Research Team
T
Tuğçe Paksoy, Associate Professor
CONTACT
A
Alima Budakçı
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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