Evaluating Injectable Platelet-Rich Fibrin with Bovine-Derived Xenogenic Bone Grafts for Treating Periodontal Intrabony Defects in Adults

What this Trial Is About

Researchers are evaluating the use of injectable platelet-rich fibrin i-PRF combined with bovine-derived xenogenic bone grafts compared to grafts alone in patients with intrabony defects and stage III periodontitis. The study aims to assess the clinical and radiographic effectiveness of this combination in improving bone gain and reducing periodontal defect areas. This randomized controlled clinical trial focuses on enhancing treatment outcomes by using i-PRF, a tissue-friendly biological material, to support graft success. The study involves two treatment groups one receiving open flap debridement surgery with a mixture of bovine-derived xenogenic bone graft and i-PRF, and the other receiving the same surgery with the graft mixed with physiological saline. The i-PRF preparation requires a 3-minute centrifugation of two 9-mL tubes of venous blood collected from each patient. Both groups undergo surgical removal of granulation tissue and calculus before graft application and flap suturing. Participants will be monitored through clinical and radiographic assessments at enrollment and during follow-up visits at 3 and 6 months. Key measures include intrabony defect fill, clinical attachment level, probing pocket depth, plaque index, gingival index, and pain assessment two weeks post-surgery. The study tracks painkiller use after surgery and observes changes in periodontal parameters to evaluate treatment effectiveness and safety over the 6-month period.

Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts