Actively Recruiting
Treatment of Metastatic Vulvar Carcinoma With Carboplatin and Paclitaxel Chemotherapy
Led by The Netherlands Cancer Institute · Updated on 2022-10-19
12
Participants Needed
1
Research Sites
467 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. Theoretically, downstaging with neo adjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive thereby diminishing the chance for morbidity.
CONDITIONS
Official Title
Treatment of Metastatic Vulvar Carcinoma With Carboplatin and Paclitaxel Chemotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Woman 18 years or older
- Signed and written informed consent
- Histologically confirmed squamous cell vulvar carcinoma
- World Health Organization performance status of 0-2
- Adequate hematological function
- Adequate hepatic function
- Adequate renal function
- Negative pregnancy test for women of childbearing potential
- Histologically or CT scan confirmed metastatic squamous cell vulvar carcinoma
- Measurable disease
- Lesion previously not irradiated
- TNM stage any T any N M1
You will not qualify if you...
- Vulvar cancer other than squamous cell carcinoma at biopsy
- Previous radiotherapy of the vulva, groins or pelvis
- Patients with metastasis limited to the pelvic lymph nodes, who can be primarily operated with curative intent
- Other diagnosis of malignancy or evidence of other malignancy for 5 years before screening for this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NKI-AVL
Amsterdam, Netherlands, 1066CX
Actively Recruiting
Research Team
F
Frederic Amant, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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