Actively Recruiting
Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery Disease
Led by China National Center for Cardiovascular Diseases · Updated on 2025-08-27
220
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
Sponsors
C
China National Center for Cardiovascular Diseases
Lead Sponsor
C
Chinese Academy of Medical Sciences, Fuwai Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to evaluate the effect of angiotensin receptor/neprilysin inhibitors (ARNI) on improving ischemic mitral regurgitation (IMR) in patients with coronary artery disease undergoing isolated coronary artery bypass grafting (CABG) through a randomized controlled clincial trial.
CONDITIONS
Official Title
Treatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fully informed and voluntarily signed informed consent
- Received coronary artery bypass grafting (CABG)
- Diagnosed with moderate ischemic mitral regurgitation on two consecutive preoperative transthoracic echocardiography according to 2021 ESC/EACTS Guidance Standards
You will not qualify if you...
- Symptomatic hypotension and/or systolic blood pressure less than 100 mmHg at screening
- Estimated glomerular filtration rate (GFR) less than 30 mL/min/1.73m2
- Serum potassium greater than 5 mmol/L at screening
- History of angioedema or unacceptable side effects while receiving ACE inhibitors or angiotensin receptor blockers (ARBs)
- Patients receiving mitral valve intervention at the same time
- Participation in other clinical trials
- Unwillingness to participate in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
China National Center for Cardiovascular Diseases
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
Research Team
L
Lianxin Chen, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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