Treatment of Osteomyelitis-associated Pressure Ulcers by Surgical Flaps and Anti-bacterial Agents in Patients with Neuromotor Disability: a Prospective Cohort Study

What this Trial Is About

This research aims to study people with neuromotor disabilities, such as those caused by spinal cord, brain, or peripheral nerve injuries, who are at high risk of developing pressure ulcers linked to bone infections called osteomyelitis. The purpose is to describe this group of patients and find factors that influence successful or unsuccessful treatment outcomes in this vulnerable population. The study is a prospective cohort conducted at a single center specialized in managing such cases. Patients included in the study are those admitted to the perioperative disability unit of a university hospital for treatment of osteomyelitis-associated pressure ulcers using surgical flaps to cover the affected area combined with antibiotic medications. The surgical approach involves bone shaving and flap coverage to close the wound, followed by antibiotics tailored based on samples taken during surgery. This is a routine care study without additional procedures for research purposes. Participants are followed up with clinic visits at 30 or 45 days after surgery, and again either in person or via teleconsultation 12 months post-surgery. Data is collected from medical records, including clinical exams, imaging, lab tests, and information about sitting, nutrition, spasticity, bladder and bowel function, bacterial testing, and antibiotic use. The main outcome measured is treatment success at 12 months after surgery, with secondary outcomes including success at 30-45 days, bacteriological test results, and death. The total duration of participation extends to one year after surgery.

Treatment of Osteomyelitis-associated Pressure Ulcers by Surgical Flaps and Anti-bacterial Agents