Actively Recruiting
Treatment of Pediatric Very High-risk Acute Lymphoblastic Leukemia in Korea
Led by Hyoung Jin Kang · Updated on 2025-06-08
74
Participants Needed
6
Research Sites
532 weeks
Total Duration
On this page
Sponsors
H
Hyoung Jin Kang
Lead Sponsor
A
Asan Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Very high-risk acute lymphoblastic leukemia
CONDITIONS
Official Title
Treatment of Pediatric Very High-risk Acute Lymphoblastic Leukemia in Korea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric patients diagnosed with ALL between the ages of 1 and 19 years at diagnosis
- Philadelphia chromosome-positive t(9;22)(q34;q11) or
- Patients with failed remission with blast > 5% on bone marrow after initial remission induction
- Hypodiploidy with less than 44 chromosomes
- E2A-HLF (Hepatic Leukemia Factor) translocation-positive
- Poor prognosis based on NGS-MRD results: In B-ALL, NGS-MRD ≥ 0.01% after consolidation and during interim maintenance; in T-ALL, NGS-MRD > 0.01% after consolidation
You will not qualify if you...
- Contraindications to medications
- Withdrawal of consent by participant or legal representative
- Pregnant or lactating women; patients of child-bearing potential must use contraception
- Medically unsuitable to participate as determined by investigator
- Participation in other interventional studies not related to this protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
2
Severance Hospital
Seoul, South Korea, 03722
Actively Recruiting
3
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
4
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
5
Seoul saint Mary's Hospital
Seoul, South Korea, 06591
Actively Recruiting
6
Pusan National University Yangsan Hospital
Yangsan, South Korea, 50612
Not Yet Recruiting
Research Team
H
Hyoung Jin Kang, Ph.D
CONTACT
H
Hyoung Jin Kang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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