Actively Recruiting
Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen
Led by University of Bern · Updated on 2025-10-06
80
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To compare the healing of intrabony periodontal defects treated with either open flap debridement and a volume-stable collagen matrix (VCMX) or a deproteinized bovine bone mineral with 10% collagen. The results will shed light on the clinical potential of VCMX in regenerative periodontal surgery and help to develop new treatment strategies.
CONDITIONS
Official Title
Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with localized or generalized periodontitis Stage III and Stage IV, Grade A-B-C
- Males and females
- Age at least 18 years and older
- Presence of interdental intra-bony defects (I, II and III walls) in either the maxilla or the mandible with a PD 26 6 mm
- Defects with an intra-bony component > 3 mm for both groups
- Intra-bony defect located only at one aspect (mesial or distal)
- Presence of at least 2 mm of keratinized soft tissue.
You will not qualify if you...
- Patients with systemic disease that could interfere with periodontal wound healing
- Prolonged antibiotic treatment or anti-inflammatory treatment within 4 weeks prior to surgery
- Pregnant or lactating
- Smokers with > 10 cig./day
- Patients with FMPS and FMBS > 25 % after completion of non-surgical periodontal therapy
- Multi-rooted teeth with furcation involvement
- Third molars
- Teeth with circumferential defects
- Interdental craters
- Written Informed Consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Bern
Bern, Switzerland, 3010
Actively Recruiting
Research Team
A
Alexandra Stähli, MD
CONTACT
A
Andrea Roccuzzo, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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