Actively Recruiting
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Led by Shanghai 10th People's Hospital · Updated on 2025-05-14
686
Participants Needed
1
Research Sites
194 weeks
Total Duration
On this page
Sponsors
S
Shanghai 10th People's Hospital
Lead Sponsor
N
National Natural Science Foundation of China
Collaborating Sponsor
AI-Summary
What this Trial Is About
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear. Our previous clinical studies demonstrated the association between olfactory impairment and PND. Moreover, our translational studies showed that anesthesia/surgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia/surgery-induced cognitive impairment. However, there was no clinical investigation to determine whether olfactory enrichment can mitigate PND in elderly patients. Therefore, we propose determining whether olfactory enrichment can prevent and/or treat PND in elderly patients.
CONDITIONS
Official Title
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Scheduled for orthopedic surgery lasting 2 hours or more under general anesthesia
- Able to complete neuropsychological tests, 3D-CAM, and CAM-S
- Native speaker of Chinese Mandarin
- Edmonton frailty scale (EFS) score of 6 or higher
You will not qualify if you...
- Having delirium before surgery as assessed by 3D-CAM
- Having a brain tumor, stroke, or mental disorders such as major depressive disorder or dementia
- Participating in other clinical studies at screening
- Unwilling to follow the study protocol or procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Tenth People's Hospital
Shanghai, China
Actively Recruiting
Research Team
Y
Yuan Shen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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