Actively Recruiting
Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant
Led by Cairo University · Updated on 2026-05-05
40
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled trial aims to compare the efficacy of methotrexate (MTX) monotherapy versus combined methotrexate and selective serotonin reuptake inhibitor (SSRI) therapy in patients with psoriasis and comorbid depression and/or anxiety. Participants will be randomly assigned to two groups: one receiving MTX alone and the other receiving MTX plus escitalopram. Clinical outcomes will be evaluated over a 6-month period, including psoriasis severity using the Psoriasis Area and Severity Index (PASI) and Body Surface Area (BSA), quality of life using the Dermatology Life Quality Index (DLQI), and psychological status using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Hamilton Depression Rating Scale (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A). The study will assess whether combination therapy provides superior clinical and psychological outcomes.
CONDITIONS
Official Title
Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged >18 and <60 years
- Moderate to severe psoriasis (PASI �3e�3d10 or BSA �3e�3d10%)
- Moderate to severe depression (BDI �3e�3d20 or HAM-D �3e�3d17) and/or moderate to severe anxiety (BAI �3e�3d16 or HAM-A �3e�3d25)
You will not qualify if you...
- Current substance abuse
- Systemic psoriasis treatment within the past 3 months
- Pregnancy or breastfeeding
- Hypersensitivity to methotrexate or escitalopram
- Erythrodermic or pustular psoriasis
- Contraindications to methotrexate (e.g., hepatic disease or malignancy)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kasralainy
Cairo, Cairo Governorate, Egypt, 11562
Actively Recruiting
Research Team
N
Naglaa Mohsen, Resident
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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