Actively Recruiting
Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment
Led by University of Pavia · Updated on 2026-02-20
40
Participants Needed
1
Research Sites
40 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled clinical trial investigates the effectiveness of trehalose powder compared to glycine powder when used in air-polishing during supportive therapy for peri-implant mucositis, a reversible inflammatory condition affecting the soft tissues around dental implants. A total of 40 adult patients with peri-implant mucositis will be enrolled and randomly assigned to receive non-surgical periodontal therapy combined with air-polishing using either trehalose powder (test group) or glycine powder (control group). Clinical parameters will be evaluated at baseline, 1 month, 3 months, and 6 months. These include Plaque Index (PI), Bleeding on Probing (BoP), Probing Pocket Depth (PPD), and Bleeding Score (BS), in order to assess plaque accumulation, inflammation, and bleeding. The primary objective is to compare the reduction in plaque levels between the two groups over the study period. Secondary outcomes include evaluation of changes in gingival inflammation and probing depths, as well as assessment of implant surface integrity through in vitro scanning electron microscopy (SEM) after treatment. The aim of the study is to determine whether trehalose powder offers improved clinical outcomes and greater implant surface preservation compared to glycine powder in the non-surgical management of peri-implant mucositis.
CONDITIONS
Official Title
Trehalose vs Glycine Air-Polishing in Peri-Implant Mucositis Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged between 18 and 70 years
- Presence of peri-implant mucositis defined as bleeding on probing around implants without radiographic bone loss beyond initial remodeling
- Visible biofilm on implant surfaces
- Ability to understand and sign informed consent
- Good oral hygiene and patient compliance
- Availability for all follow-up visits at 1, 3, and 6 months
You will not qualify if you...
- Presence of systemic conditions that may affect healing such as uncontrolled diabetes or immunosuppression
- Current smokers or former smokers who quit less than 6 months ago
- Pregnant or breastfeeding women
- Use of antibiotics or anti-inflammatory drugs in the 3 months prior to baseline
- Presence of peri-implantitis with bleeding on probing and radiographic bone loss
- History of head and neck radiotherapy
- Presence of pacemakers or cardiac stimulators
- Neurological or psychological disorders affecting study compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
Pavia, Lombardy, Italy, 27100
Actively Recruiting
Research Team
A
Andrea Scribante, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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