Actively Recruiting
Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3)
Led by General Hospital of Shenyang Military Region · Updated on 2026-04-27
600
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The effect of head position as a nonpharmacological therapy on acute ischemic stroke (AIS) remains inconclusive. Recent HOPES2 (Head dOwn-Position for acutE moderate ischemic Stroke with large artery atherosclerosis) suggest the safety, feasibility, and potential benefit of the head-down position (HDP) in acute ischemic stroke. The current study aims to investigate the efficacy and safety of HDP in acute moderate ischemic stroke patients with large artery atherosclerosis.
CONDITIONS
Official Title
Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Acute ischemic stroke confirmed by NCCT or MRI
- Moderate neurological deficit with NIHSS score between 6 and 16 within 24 hours of onset, or worsening from mild to moderate within 24 hours with at least 4 point increase in NIHSS even if onset is beyond 24 hours
- Probable large artery atherosclerosis based on TOAST criteria with artery stenosis 50% or greater or occlusion
- Stroke affecting anterior circulation (internal carotid artery, M1 or M2 segment of middle cerebral artery)
- First stroke or past stroke without obvious neurological deficit (modified Rankin Scale score 2 or less)
- Signed informed consent
You will not qualify if you...
- Pre-stroke disability with modified Rankin Scale score 3 or higher
- Disturbance of consciousness
- Planned or completed thrombolysis or mechanical thrombectomy
- Hemorrhagic stroke or mixed ischemic and hemorrhagic stroke
- Serious comorbid conditions such as liver or kidney failure or malignant tumors
- Other stroke causes including cardiogenic embolism, arteritis, arterial dissection, or moyamoya disease
- History of intracerebral hemorrhage within the past year
- Contraindications to head-down position such as active vomiting, pneumonia, or uncontrolled heart failure
- Planned carotid or intracranial revascularization within 3 months
- Severe uncontrolled hypertension (systolic over 180 mmHg or diastolic over 100 mmHg)
- Cardiac insufficiency of NYHA Class II or higher
- Pregnant or breastfeeding women
- Other serious diseases
- Participation in other clinical trials within the last 3 months
- Any other conditions making the patient unsuitable for the study as determined by the researcher
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Neurology, General Hospital of Northern Theater Command
Shenyang, China, 110016
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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