Actively Recruiting
Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)
Led by Columbia University · Updated on 2026-04-09
90
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD. The main questions it aims to answer are: Does AMBET reduce PTSD symptoms in survivors of cardiac arrest? How do the benefits of AMBET compare to PCT? Participants will: * Be randomly assigned to receive either AMBET or PCT * Attend 12 hours of individual psychotherapy sessions over about 12 weeks * Complete short weekly surveys about their mood and behaviors online * Wear a Fitbit device to track sleep and activity during the study * Do brief homework assignments between sessions
CONDITIONS
Official Title
Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 81 years old at the time of consent
- Fluent in English
- Medical history of cardiac arrest more than 3 months ago
- Clinically elevated PTSD symptoms with CAPS-5 score 25 or higher
- Resident of the United States
You will not qualify if you...
- Lifetime history of primary psychotic or bipolar disorders
- Current moderate or severe substance use disorder within past 6 months
- Active suicidal thoughts with intent in past 12 months or suicide attempt in past 24 months
- Significant cognitive impairment with MMSE score less than 25
- Started new psychotropic medication less than 3 months ago
- Cardiac arrest caused by non-cardiac events like drowning, trauma, or overdose
- Terminal illness with life expectancy less than 1 year
- Currently undergoing psychotherapy for PTSD
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
Y
Yuval Neria, Ph.D.
CONTACT
M
Maja Bergman, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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