Actively Recruiting
A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies
Led by AtlasMedx, Incorporated · Updated on 2025-05-01
122
Participants Needed
4
Research Sites
320 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
ATLAS-101 is a Phase I/II clinical trial of AMXI-5001 in adult participants with advanced malignancies who have previously failed other therapies. The study has two phases. The purpose of Phase I (Dose Escalation) is to confirm the appropriate treatment dose and Phase II (Dose Expansion) is to characterize the safety and efficacy of AMXI-5001.
CONDITIONS
Official Title
A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Pathologically confirmed advanced or metastatic malignancy that is intolerant, refractory, or progressed after standard therapy
- Measurable tumors by standard imaging or laboratory tests
- Eastern Co-operative Oncology Group (ECOG) performance status of 0 or 1
- Able to understand and sign informed consent
You will not qualify if you...
- Receiving cancer treatment at enrollment
- Any clinically significant disease affecting a major organ system
- Significant cardiovascular disease or abnormal electrocardiogram (ECG) findings
- Use of strong CYP3A4 inhibitors or inducers within 7 days before starting study therapy and during the study
- History of another malignancy within the past 2 years or current malignancy other than the target cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University of California, Los Angles (UCLA) Department of Medicine - Hematology/Oncology
Los Angeles, California, United States, 90404
Actively Recruiting
2
Johns Hopkins
Baltimore, Maryland, United States, 21218
Actively Recruiting
3
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
4
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
B
Bonnie Wettersten, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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