Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07033416

A Trial Of Approach Bias Modification Training During Treatment For Cocaine Use Disorder

Led by ASST Fatebenefratelli Sacco · Updated on 2025-12-24

60

Participants Needed

1

Research Sites

30 weeks

Total Duration

On this page

Sponsors

A

ASST Fatebenefratelli Sacco

Lead Sponsor

M

Monash University

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to investigate if the intervention "Approach Bias Modification" (ABM) can low cocaine craving in people with Cocaine Use Disorder (CUD). The main question this clinical trial aims to answer is how many days participants can be in abstinence from cocaine after 4 ABM sessions. ABM is a computerised training aiming to train the participants to: * avoid drug-related images by pushing a joystick which causes the image to disappear; * approach positive images by pulling a joystick which causes the image to expand. Researchers will compare participants treated with ABM to those who receive Treatment As Usual (TAU) condition to see if ABM training for CUD is more effective in increasing the number of abstinent days. * Participants will attend 1 ABM session per week for a total of 4 sessions, each lasting 15 minutes. * Both cocaine and non-cocaine positive images relative to the subjective values or interests (i.e. effects, sport, music, nature, work, etc.) are presented to the participant, in portrait or landscape orientation. * Participants are instructed to push the joystick if the image is portrait-oriented (cocaine-related images) or to pull the joystick if it is landscape-oriented (positive images). * At 1 and 3-month-follow up, participants will complete self-report questionnaires to measure abstinence days and describe the effect of ABM on cocaine use, dependence symptoms, and approach bias.

CONDITIONS

Official Title

A Trial Of Approach Bias Modification Training During Treatment For Cocaine Use Disorder

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants must be aged at least 18 years
  • Current DSM 5 TR Cocaine Use Disorder diagnosis
  • Sufficient Italian language proficiency to understand information sheet, questionnaires, and instructions
  • Signed informed consent form
Not Eligible

You will not qualify if you...

  • Neurological disorder, injury, or brain trauma with loss of consciousness longer than 30 minutes
  • Severe psychiatric disorder as judged clinically
  • Use of antipsychotic medication
  • Intellectual disability
  • Missing informed consent
  • Planned absence during the one-month training period

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Struttura Semplice Servizio Dipendenze

Milan, Milano, Italy, 20131

Actively Recruiting

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Research Team

S

Stefania Cheli, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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A Trial Of Approach Bias Modification Training During Treatment For Cocaine Use Disorder | DecenTrialz