Actively Recruiting
Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance
Led by University of Texas Southwestern Medical Center · Updated on 2025-06-11
291
Participants Needed
1
Research Sites
607 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective study to determine if the use of curcumin randomized against placebo will reduce cancer progression in patients with prostate cancer undergoing active surveillance.
CONDITIONS
Official Title
Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 89 years
- Biopsy confirmed low-risk, localized prostate cancer with at least 8 biopsy cores
- Biopsy may have been done within the last 12 months
- Cancer involves 4 or fewer separate locations in the prostate
- Gleason score 6 or less with no pattern 4
- Clinical stage T1c to T2a/b
- Serum PSA 15 ng/ml or less
- Life expectancy greater than 5 years
You will not qualify if you...
- Previous prostate cancer treatments such as radiotherapy, chemotherapy, hormonal therapy, oral glucocorticoids, GnRH analogues, or prostatectomy
- Use of any 5-alpha-reductase inhibitor within 6 months before screening
- Use of anabolic steroids or drugs with antiandrogenic effects
- Prostate volume greater than 150 cm3
- Taking antiplatelet or anticoagulant medications or having a bleeding disorder (81 mg aspirin allowed with monitoring)
- History of gastric or duodenal ulcers or untreated acid reflux syndromes (stable GERD treatment allowed)
- Current use of curcumin or unwillingness to stop or avoid curcumin during the study
- History of gallbladder problems, gallstones, or biliary obstruction unless gallbladder has been removed
AI-Screening
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Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
C
Catherine Robinson
CONTACT
M
Maricruz Ibarra
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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