Study of D-mannose Daily Supplement to Prevent Recurrent Urinary Tract Infections in Post-menopausal Women Aged 55 to 85

What this Trial Is About

Researchers are evaluating the use of D-mannose supplementation to prevent recurrent urinary tract infections rUTI in post-menopausal women. This randomized, double-blind, placebo-controlled study aims to improve understanding of rUTI prevention in this population, which is disproportionately affected and understudied. The study tests whether daily D-mannose intake over 6 months and up to one year effectively reduces the occurrence of uncomplicated rUTIs compared to placebo. Participants will be randomly assigned in a 21 ratio to receive either D-mannose 2 grams daily, taken as four 500 mg capsules or a placebo for 12 months. The study follows CONSORT guidelines and includes two groups one receiving the active supplement and the other receiving a placebo. The study aims to enroll 90 women who are currently free of UTI but have a history of recurrent infections. During the study, participants will attend follow-up appointments to monitor urinary tract health through urine cultures and symptom assessments. Researchers will collect data on failure rates, number of antibiotic treatments for UTI, symptom severity, and any serious adverse events related to D-mannose over an average follow-up of five years. This allows long-term observation of the supplements impact on rUTI prevention and safety.

A Trial of D-mannose for the Prophylaxis of Recurrent Urinary Tract Infections