Actively Recruiting
Trial Designs for Evaluating Migraine Treatment
Led by University of Aarhus · Updated on 2026-04-13
128
Participants Needed
2
Research Sites
198 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, advanced balanced placebo design, patients with episodic migraine will receive six treatment conditions in a randomized order.
CONDITIONS
Official Title
Trial Designs for Evaluating Migraine Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- At least 1-year history of migraine with or without aura based on International Classification of Headache Disorders criteria
- Episodic migraine with 1 to less than 15 headache days per month featuring migraine symptoms on 2 to 8 days per month for over 3 months
- Previous or current use of triptans for acute migraine treatment
- Ability to speak and read Danish
You will not qualify if you...
- Chronic migraine or history of chronic migraine in the past 12 months
- Other primary headache types except infrequent tension-type headache
- Secondary headache disorders including medication overuse headache
- Severe psychiatric, vascular, or liver diseases
- Use of opioids or barbiturates in the month before screening
- Current use of certain preventive migraine treatments like onabotulinum toxin A or CGRP monoclonal antibodies
- Contraindications or inability to tolerate triptans
- Current substance use disorder
- Implanted metallic or electronic device in the head
- Presence of cardiac pacemaker or implanted/wearable defibrillator
- Use of illegal psychotropic drugs less than one week before study; cannabis less than four weeks before study
- Current or planned pregnancy and lactation as confirmed by tests and contraception guidelines
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Dept. of Psychology and Behavioural Sciences
Aarhus C, Denmark, 8000
Not Yet Recruiting
2
Department of Neurology, Aarhus University Hospital
Aarhus N, Denmark, 8200
Actively Recruiting
Research Team
S
Sigrid Juhl Lunde, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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