Actively Recruiting
A Trial Evaluating Novel Technologies for the Diagnosis of Asthma The LUNG-TECH Trial
Led by Portsmouth Hospitals NHS Trust · Updated on 2025-07-17
356
Participants Needed
1
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial aims to evaluate novel diagnostic technologies for asthma in 3 different pathways providing the necessary evidence-base to allow adoption into clinical practice: * Pathway 1 evaluates whether the technology can distinguish between people with asthma and healthy volunteers, and other respiratory conditions in a well characterised secondary-care population and whether the parameters they measure correlate with the current standard diagnostic tests; * Pathway 2 assesses whether the technology can accurately diagnose asthma (either independently or alongside current diagnostic tests) in a primary care population of patients where there is a clinical suspicion of asthma; * Pathway 3 explores the ability of the technology to identify clinically important phenotypic characteristics which are difficult to measure in primary care and/or significantly impact on patient management and treatment The novel technology and devices will be entered into the pathway most suited to their stage of development, with this study design also allowing information collected for participants with a confirmed diagnosis of asthma in pathways 1 or 2 to be included in pathway 3. Participants will undergo the investigations currently used to diagnose asthma as well as using the novel devices being investigated in the relevant pathway.
CONDITIONS
Official Title
A Trial Evaluating Novel Technologies for the Diagnosis of Asthma The LUNG-TECH Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis confirmed by a specialist supported by evidence within the last 5 years including variable and/or reversible airflow obstruction, significant peak expiratory flow variability, airway hyperresponsiveness, or T2 airway inflammation
- Poor asthma control with an ACQ-6 score of 1.5 or higher
- Not currently on biologic therapy for severe asthma
You will not qualify if you...
- Significant chest wall, neuromuscular, cardiac, or other co-morbidity affecting lung function tests
- Respiratory infection or exacerbation requiring systemic corticosteroids or antibiotics within the last 2 weeks
- Current smokers or ex-smokers with over 20 pack-years smoking history (except certain asthma and COPD groups)
- Unable to provide informed consent or complete study procedures
- Healthy volunteers must have no respiratory disease, no recent respiratory infection treatment, be never smokers or ex-smokers with 10 or fewer pack-years who quit at least 6 months ago, and have non-obstructive spirometry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Portsmouth Hospitals University NHS Trust
Portsmouth, Hampshire, United Kingdom, PO6 3LY
Actively Recruiting
Research Team
J
Joe Mr Shoebridge
CONTACT
L
Laura Marshall
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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