Actively Recruiting
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Led by Montefiore Medical Center · Updated on 2026-04-21
400
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
M
Montefiore Medical Center
Lead Sponsor
W
Westat
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cigarette smoking is now the leading killer of people with HIV (PWH) in the US, and most cessation strategies tried to date have failed to increase long-term quit rates. An "all or none" approach to smoking cessation in PWH offers little benefit to the large majority of PWH who are unable or unwilling to quit. In this proposal we argue that a harm reduction approach (i.e., cut down, get screened for lung cancer, control your blood pressure and cholesterol) has the potential to yield significant benefits in terms of the private and public health of PWH in the US.
CONDITIONS
Official Title
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 79 years
- Current cigarette smoker (smoked more than 100 cigarettes in lifetime and smoked in past 7 days)
- Lab-confirmed HIV infection
- Willing to participate in web-based tobacco treatment and take varenicline
- Has internet access at least weekly and can read at 7th grade level or higher
- Willing to be randomized to one of the two study groups
You will not qualify if you...
- Pregnant
- No insurance coverage for specialty referrals
- Contraindication to varenicline
- Currently receiving other smoking cessation treatments
- Seen in Cardiometabolic Clinic in past 12 months
- Spouse, partner, or roommate of an enrolled participant to avoid study contamination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
Research Team
J
Jonathan Shuter, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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