Actively Recruiting
A Trial of HRS-4508 Combined With Other Antitumor Therapies in Subjects With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Led by Jiangsu HengRui Medicine Co., Ltd. · Updated on 2025-12-12
100
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is being conducted to evaluate the efficacy, safety, and ORR of HRS-4508 combined with other antitumor therapies in subjects with locally advanced or metastatic non-small cell lung cancer; Evaluate the pharmacokinetic (PK) characteristics of HRS-4508 and other efficacy endpoints for the treatment of locally advanced or metastatic non-small cell lung cancer.
CONDITIONS
Official Title
A Trial of HRS-4508 Combined With Other Antitumor Therapies in Subjects With Locally Advanced or Metastatic Non-small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years old
- Diagnosed with locally advanced or metastatic non-small cell lung cancer that has failed or is intolerant to standard treatments
- ECOG performance status of 0 or 1
- Expected to live at least 12 weeks
- Have at least one measurable tumor lesion outside the central nervous system according to RECIST v1.1
- Willing to follow the study protocol and attend follow-up visits
You will not qualify if you...
- Untreated or active central nervous system tumor metastases or history of meningeal metastasis
- Severe infections or major surgeries within the past 4 weeks
- Previous or current other malignant tumors
- Severe nausea, vomiting, or gastrointestinal conditions affecting oral medication use
- Major surgeries (except diagnosis or biopsy) within 28 days before first dose or minor surgery within 7 days before first dose
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China, 200430
Actively Recruiting
2
Zhejiang Tumor Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
Research Team
L
Liju Zong
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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