Actively Recruiting
A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
Led by Christoph Berger · Updated on 2026-05-05
376
Participants Needed
13
Research Sites
204 weeks
Total Duration
On this page
Sponsors
C
Christoph Berger
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced community-acquired pneumonia. The main question it aims to answer is: Is antibiotic treatment needed in Mycoplasma pneumoniae (a specific bacterium) induced pneumonia? Participants will receive either a placebo or a antibiotic treatment and track their symptoms and vital signs until they are healthy. Researchers will then compare the length of symptoms between the placebo and the antibiotic group.
CONDITIONS
Official Title
A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 3 to 17 years presenting to emergency department for ambulatory or general ward care
- Clinical diagnosis of community-acquired pneumonia confirmed by treating physician
- Fever of 38.0°C or higher measured or reported within last 24 hours
- Tachypnea above age-specific reference during emergency department assessment
- Written consent for screening phase signed by parents/legal guardians and patient if 14 years or older
- Positive Mycoplasma pneumoniae IgM lateral flow assay test for intervention phase
- Written informed consent for intervention phase signed by parents/legal guardians and patient if 14 years or older
You will not qualify if you...
- Allergy to azithromycin or contraindications such as cardiovascular disease including bradycardia, arrhythmias, or QT-interval prolongation
- Myasthenia gravis
- Chronic lung disorders excluding asthma, cystic fibrosis
- Primary or secondary immunodeficiency
- Sickle-cell anemia
- Severe cerebral palsy
- History of recurrent pneumonia (two or more episodes) or severe pneumonia with ICU admission or complications
- Antibiotic treatment against Mycoplasma pneumoniae within previous 7 days
- Direct referral to ICU from emergency department
- Inability to take oral medication
- Parents unlikely to reliably complete follow-up visits and questionnaires due to language barriers or distance
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 13 locations
1
Children's Hospital Aarau, Switzerland
Aarau, Canton of Aargau, Switzerland, 5001
Active, Not Recruiting
2
University of Basel Children's Hospital, Switzerland
Basel, Canton of Basel-City, Switzerland, 4056
Actively Recruiting
3
University Children's Hospital Bern, Switzerland
Bern, Canton of Bern, Switzerland, 3010
Actively Recruiting
4
Department of Pediatrics, Fribourg Hospital, Switzerland
Fribourg, Canton of Fribourg, Switzerland, 1708
Not Yet Recruiting
5
Children's Hospital of Geneva, University Hospitals of Geneva, Switzerland
Geneva, Canton of Geneva, Switzerland, 1205
Not Yet Recruiting
6
Children's Hospital of Central Switzerland, Switzerland
Lucerne, Canton of Lucerne, Switzerland, 6000
Actively Recruiting
7
Children's Hospital of Eastern Switzerland St. Gallen
Sankt Gallen, Canton of St. Gallen, Switzerland, 9006
Actively Recruiting
8
Department of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, Switzerland
Lausanne, Canton of Vaud, Switzerland, 1011
Not Yet Recruiting
9
Department of Pediatrics, Cantonal Hospital Winterthur, Switzerland
Winterthur, Canton of Zurich, Switzerland, 8401
Actively Recruiting
10
University Children's Hospital Zurich, Switzerland
Zurich, Canton of Zurich, Switzerland, 8032
Actively Recruiting
11
Department of Pediatrics, Triemli Hospital Zurich, Switzerland
Zurich, Canton of Zurich, Switzerland, 8063
Not Yet Recruiting
12
Institute of Pediatrics of Southern Switzerland, EOC, Bellinzona, Switzerland
Bellinzona, Canton Ticino, Switzerland, 6500
Not Yet Recruiting
13
Department of Pediatrics, Cantonal Hospital Graubuenden, Switzerland
Chur, Kanton Graubünden, Switzerland, 7000
Actively Recruiting
Research Team
P
Patrick M Meyer Sauteur, PD Dr. Dr. med.
CONTACT
M
Margarete Von Wantoch, Dr. rer. nat.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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