Actively Recruiting
Trial of Precision Medicine in Emergency Departments
Led by University of Florida · Updated on 2025-05-11
1200
Participants Needed
3
Research Sites
202 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Human Genome Research Institute (NHGRI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objectives of this study are to (1) test the feasibility of the clinical implementation of preemptive pharmacogenetic (PGx) testing in the emergency department (ED) and (2) determine if PGx testing (with appropriate decision support) decreases ED return visits and hospitalizations. We will conduct a randomized, controlled, pragmatic clinical trial assessing both the real-world effectiveness as well as implementation outcomes using a targeted PGx testing panel in several UF Health EDs.
CONDITIONS
Official Title
Trial of Precision Medicine in Emergency Departments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 40 years or older presenting to a participating ED
- Received a new order or prescription for a selected pharmacogenetic medication lasting more than 7 days during the current ED visit or within the past 30 days
- Had at least two prior emergency department or urgent care visits within the past 12 months
You will not qualify if you...
- Prior clinical pharmacogenetic test results for relevant genes recorded in the EHR
- History of liver or kidney transplant
- History of severe liver disease (Child-Pugh C) or severe kidney disease with eGFR less than 15 ml/min
- Any medical condition that would prevent completing the study
- Prisoners, wards of the state, or patients held under Baker Act or Marchman Act
- Life expectancy less than 6 months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
UF Health Emergency Department
Gainesville, Florida, United States, 32610
Not Yet Recruiting
2
UF Health Jacksonville Downtown Emergency Department
Jacksonville, Florida, United States, 32209
Actively Recruiting
3
UF Health Jacksonville North Emergency Department
Jacksonville, Florida, United States, 32218
Actively Recruiting
Research Team
E
Erica N Elwood, MHA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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