Actively Recruiting
A Trial on Prophylactic Clipping to Prevent Post-polypectomy Bleeding After Colonoscopy in Direct Oral Anticoagulant Users
Led by Chinese University of Hong Kong · Updated on 2024-08-29
584
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators hypothesize that prophylactic clipping after colonoscopic polypectomy can reduce risk of delayed PPB among DOAC users. The investigators also hypothesize that pre-endoscopy drug level can predict the risk of hemorrhagic complications after the procedure.
CONDITIONS
Official Title
A Trial on Prophylactic Clipping to Prevent Post-polypectomy Bleeding After Colonoscopy in Direct Oral Anticoagulant Users
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Active users of any direct oral anticoagulant (DOAC)
- Scheduled for elective colonoscopy for colorectal cancer screening, polyp surveillance, or investigation of symptoms like anemia or past gastrointestinal bleeding
- At least 18 years old
- Provided written informed consent
You will not qualify if you...
- Absolute contraindications to colonoscopy
- Medical conditions preventing interruption of DOAC for the procedure
- Medical conditions requiring uninterrupted dual antiplatelet therapy (single antiplatelet therapy allowed)
- Active gastrointestinal bleeding
- Clinically significant bleeding tendency such as decompensated cirrhosis or severe thrombocytopenia
- Severe renal impairment with creatinine clearance less than 15 ml/min
- Pregnancy or breastfeeding
- Advanced comorbid conditions defined as American Society of Anesthesiologists grade 4 or above
- Unable to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Shatin, New Territories, Hong Kong
Actively Recruiting
Research Team
L
Louis Ho Shing Lau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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