Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06843356

Trial of Rescue Endovascular Treatment for Progressive Acute Mild Ischemic Stroke With Basilar Artery Occlusion With Extended Time Window

Led by First Affiliated Hospital of Wannan Medical College · Updated on 2025-04-15

159

Participants Needed

1

Research Sites

134 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

A prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial to evaluate whether best medical management (BMM) combined with endovascular therapy (EVT) improves neurological outcomes compared to BMM alone in patients with progressive acute mild ischemic stroke due to basilar artery occlusion within an extended time window.

CONDITIONS

Official Title

Trial of Rescue Endovascular Treatment for Progressive Acute Mild Ischemic Stroke With Basilar Artery Occlusion With Extended Time Window

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Symptoms and signs consistent with basilar artery ischemia
  • Basilar artery or vertebral artery occlusion confirmed by CTA, MRA, or DSA; vertebral artery occlusion must completely block blood flow along the basilar artery
  • First-time onset meeting criteria for mild ischemic stroke diagnosis with NIHSS score less than 6
  • Symptom progression within 7 days of first onset
  • Symptom progression defined as NIHSS score increase of 4 points or consciousness level increase of 2 points from initial NIHSS score
  • Time from symptom onset to randomization greater than 24 hours
  • Symptom progression to randomization time 24 hours or less
  • NIHSS score 10 or less before randomization
  • pc-ASPECTS score 6 or greater before randomization
  • Patient or family willing to comply with protocol requirements and sign informed consent form
Not Eligible

You will not qualify if you...

  • Symptom progression due to intracranial hemorrhage, brain edema, or other clear causes such as infarct hemorrhagic transformation, new infarction in non-occluded vascular regions, severe infection, high fever, heart or kidney dysfunction, hypovolemia, or severe electrolyte disturbances
  • Modified Rankin Scale score greater than 2
  • Factors in target vessel preventing completion of endovascular treatment
  • Multiple vessel occlusions
  • Chronic basilar artery occlusion confirmed by imaging or assessed by investigator
  • Untreated intracranial aneurysms, intracranial tumors (except small meningiomas), or intracranial vascular malformations
  • Intracranial hemorrhage within past 6 months including parenchymal, intraventricular, or subarachnoid hemorrhage
  • Gastrointestinal or urinary tract bleeding, acute myocardial infarction, cranial trauma, or major surgery within past month
  • Active bleeding, coagulation disorders, or uncorrectable bleeding tendencies
  • Platelet count less than 40 x10^9/L or INR greater than 2 during anticoagulation therapy
  • Severe heart, liver, or kidney dysfunction or other severe systemic late-stage diseases
  • Known allergy to iodine contrast agents or treatment-related drugs
  • Medically uncontrolled refractory hypertension (persistent systolic BP >185 mmHg or diastolic BP >110 mmHg), unless controlled with medication
  • Uncontrollable blood glucose less than 2.8 mmol/L or greater than 22.2 mmol/L
  • Pregnancy or breastfeeding
  • Life expectancy less than 6 months
  • Participation in other clinical studies that may affect outcome assessment
  • Investigator judgment of unsuitability due to mental illness, cognitive or emotional disorders preventing understanding or compliance with study procedures and follow-up

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

First Affiliated Hospital of Wannan Medical College

Wuhu, Anhui, China, 241000

Actively Recruiting

Loading map...

Research Team

X

Xianjun Huang, PhD

CONTACT

W

Wen Sun, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here