Actively Recruiting
A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy
Led by Alexandra J. Berger Eberhardt, MD · Updated on 2025-11-24
50
Participants Needed
1
Research Sites
236 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to see if nitrous oxide is safe and effective to use during during vasectomies performed in a clinic/in-office setting. This trial will compare self-administered nitrous oxide versus a placebo (oxygen) during office vasectomy. The main questions it aims to answer are: * Whether self-administered low dose (20-45%) nitrous oxide (SANO) reduces intraoperative anxiety and catastrophizing during office vasectomy. * To examine whether SANO reduces intraoperative pain or alters procedure duration, the rate of adverse events, or urologists' perception of ease and patient tolerance of the procedure. Participants will be asked to complete multiple surveys pre-procedure, intra-procedure, and post-procedure.
CONDITIONS
Official Title
A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 - 85 at the time of screening
- Desiring vasectomy for family planning purposes
- Able to understand and complete patient questionnaires
- Willing and able to provide written consent to participate in the study
You will not qualify if you...
- Patients with unilateral absence of the vas deferens
- Patients who are deemed by study surgeons to have anatomy no amendable for office procedure
- Patients who decline office vasectomy and request monitored anesthesia care
- Patients taking benzodiazepine or narcotic medication daily or within 24 hours of the procedure
- Patients with contraindications to nitrous oxide including:
- Inner ear, bariatric, or eye surgery within the past 2 weeks
- Current emphysematous blebs
- Severe B-12 deficiency
- History of bleomycin chemotherapy within the last year
- Class III or higher heart failure
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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