What is this study studying for healthy adults with low energy levels?

This study is evaluating whether supplements of Ginseng or Cordyceps affect aerobic fitness, lactate processing, and nitric oxide levels in adults aged 40 to 65. The goal is to understand potential benefits on energy, mood, and recovery. Applied Food Sciences Inc. sponsors this research to explore these supplements' effects.

Who may be eligible for this healthy adult clinical trial?

Adults aged 40 to 65 who are generally healthy, recreationally active, and have a body mass index between 18.5 and 34.9 may be eligible. Smokers and individuals with certain medical conditions or recent supplement use are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this healthy adult clinical trial?

Study-related care, including the supplements and all trial visits, is provided at no cost. However, personal travel expenses vary and may not be covered.

Actively Recruiting

Phase Not Applicable

Age: 40Years - 65Years

All Genders

Healthy Volunteers

ID07729943

Evaluating Ginseng and Cordyceps Supplements for Aerobic Fitness, Lactate Processing, and Nitric Oxide in Adults Aged 40 to 65 Over 30 Days

Led by Applied Food Sciences Inc. · Updated on 2026-07-28

Participants Needed

Research Sites

5 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating the effects of Ginseng and Cordyceps supplements on aerobic capacity, lactate kinetics, and nitric oxide levels in healthy adults aged 40 to 65. This randomized, double-blind, placebo-controlled trial involves 75 participants and aims to assess potential benefits related to energy, recovery, mood, and quality of life over a 30-day period. Participants are randomly assigned to one of three groups receiving either 250 mg Panax Ginseng extract, 1 gram Cordyceps Militaris extract, or a placebo with maltodextrin. The study lasts 30 days, with supplementation taken daily. There are three study visits screening, baseline Day 0, and Day 30, during which various physical and biochemical tests are performed. Participants will complete questionnaires on recovery, mood, energy, fatigue, and quality of life at baseline and the end of the study. Physical assessments include VO2 max test, time-to-exhaustion, handgrip strength, and isometric mid-thigh pull. Blood tests will measure circulating nitratesnitrites, circulatory efficiency, and lactate kinetics. Side effects and adverse events will be monitored throughout the study to ensure safety.

CONDITIONS

Brief Title

A Trial to Study the Effects of Ginseng and Cordyceps on Aerobic Capacity, Lactate Kinetics, and Nitric Oxide

Who Can Participate

Age: 40Years - 65Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Provide voluntary signed and dated informed consent.
Be in good health and able to participate in cognitive performance testing as determined by assessment, medical history, and routine blood chemistries.
Between 40 and 65 years of age (inclusive).
Body Mass Index of 18.5-34.9 (inclusive).
Body weight of at least 110 pounds.
Normotensive with seated, resting systolic blood pressure less than 140 mm Hg and diastolic blood pressure less than 90 mm Hg.
Normal supine, resting heart rate less than 90 per minute.
Able to provide an adequate blood draw.
Willing to discontinue dietary supplements started within the past month followed by a 2-week washout prior to participation.
Willing to duplicate previous 24-hour diet, refrain from caffeine and alcohol for 24 hours, refrain from exercise for 48 hours prior to each trial, and fast for 10 hours prior to each visit.
Recreationally active with at least 3 exercise sessions per week.

You will not qualify if you...

Smokers.
History of malignancy in the previous 5 years except for non-melanoma skin cancer.
Prior gastrointestinal bypass surgery.
Gastrointestinal or metabolic diseases affecting nutrient absorption or metabolism.
Chronic medically diagnosed inflammatory conditions.
Medical history of metabolic, cardiovascular, hepatorenal, musculoskeletal, autoimmune, or neurologic disease.
Use of performance enhancing drugs.
Use of anti-inflammatory supplements or medications started within 4 weeks.
Use of ergogenic supplements started within 4 weeks.
Excessive caffeine intake over 400 mg per day.
Known sensitivity to any ingredient in the test formulations.
Women currently pregnant, trying to become pregnant, or breastfeeding.
Any other conditions that could confound results or increase risk according to medical staff opinion.

Research Team

Michael Michael La Monica, Ph.D., CSCS

Tim N Ziegenfuss, PhD, CSCS, FISSN

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Evaluating Ginseng and Cordyceps Supplements for Aerobic Fitness, Lactate Processing, and Nitric Oxide in Adults Aged 40 to 65 Over 30 Days

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria