Actively Recruiting
A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients
Led by The University of Queensland · Updated on 2026-03-30
280
Participants Needed
12
Research Sites
306 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
BEAT-BK will see the effect of immunosuppression reduction/modification with and without IVIG on BKPyV infection, allograft function, allograft loss, acute transplant rejection, immunosuppression load and death in kidney and simultaneous kidney pancreas transplant recipients with polyomavirus infections (BKPyV).
CONDITIONS
Official Title
A Trial to Treat Polyomavirus Infections (BKPyV) in Kidney and Simultaneous Kidney Pancreas Transplant Recipients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 2 years or above
- Received a kidney or simultaneous pancreas-kidney transplant
- Have BKPyV-Viremia with viral count ≥ 5,000 copies/mL or histological confirmation of BKPyVAN within 3 weeks before randomization
- Able to provide informed consent or have consent given by a parent, guardian, or authorized person if under 18 years
You will not qualify if you...
- Contraindicated for intravenous immunoglobulin (IVIG) treatment
- Currently have active acute rejection within the last 3 months
- Considered unsafe for enrollment by treating clinicians
- Have a limited life expectancy of less than 12 months
- Receiving Belatacept as part of immunosuppression
- Currently undergoing or previously received viral-specific T-cell therapy for BK viremia
- Prior infection and treatment for BKPyV-Viremia
- Received IVIG treatment in the past with last treatment less than 4 weeks before randomization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Canberra Hospital
Canberra, Australian Capital Territory, Australia, 2605
Actively Recruiting
2
John Hunter Hospital
New Lambton Heights, New South Wales, Australia, 2305
Actively Recruiting
3
Prince of Wales Hospital
Randwick, New South Wales, Australia, 2031
Actively Recruiting
4
Royal Prince Alfred Hospital
Sydney, New South Wales, Australia, 2050
Actively Recruiting
5
The Childrens Hospital Westmead
Sydney, New South Wales, Australia, 2145
Actively Recruiting
6
Western Sydney Local Health District (Westmead Hospital)
Westmead, New South Wales, Australia, 2145
Actively Recruiting
7
Queensland Children's Hospital
Brisbane, Queensland, Australia, 4101
Actively Recruiting
8
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Actively Recruiting
9
Flinders Medical Centre
Adelaide, South Australia, Australia, 5042
Actively Recruiting
10
Monash Health
Melbourne, Victoria, Australia, 3168
Actively Recruiting
11
Perth Children's Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
12
Sir Charles Gairdner Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
Research Team
M
Misa Matsuyama, PhD
CONTACT
P
Pushparaj Velayudham
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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