Actively Recruiting
A Trial Utilizing 18F-FS PG PET to Guide Therapy in Hepatocellular Carcinoma
Led by M.D. Anderson Cancer Center · Updated on 2026-02-19
60
Participants Needed
1
Research Sites
343 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the relationship between 18F-FSPG uptake in HCC lesions, ctDNA in blood and clinical response to Y90 radioembolization therapy in patients with hepatocellular carcinoma (HCC) by SOC imaging.
CONDITIONS
Official Title
A Trial Utilizing 18F-FS PG PET to Guide Therapy in Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of hepatocellular carcinoma (HCC) with at least one of the following: liver mass with non-rim arterial phase hyperenhancement (APHE) and additional major features based on LI-RADS criteria; lesions meeting LI-RADS 4 or 5 criteria; suggestive imaging plus Alpha Fetoprotein (AFP) > 200 mg/dL; tumor confirmed by arteriography; or pathologic confirmation of tumor.
- Candidates for Y90 radioembolization monotherapy.
- Completed conventional imaging and staging including CT before investigational PET studies.
- Age 18 years or older.
- Women and men of child-bearing potential must agree to use adequate contraception during the study and per MD Anderson Pregnancy Assessment Policy.
- Ability to understand and sign informed consent.
You will not qualify if you...
- Under 18 years of age.
- Not candidates for Y90 radioembolization monotherapy.
- Pregnant or breastfeeding.
- Poorly controlled diabetes mellitus (fasting blood glucose > 200 mg/dL).
- Psychiatric illness or social situations limiting study compliance.
- Not recovered from adverse events or allergic reactions to similar compounds.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Simone Krebs, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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